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Capturing the diversity of protein modifications on presented tumor antigens

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Post-translational modifications (PTMs) alter the structure, properties and functions of proteins in all aspects of biology. A new computational pipeline, termed protein modification integrated search engine (PROMISE), reveals the impact these modifications might have on the presentation of cancer antigens to T cells.

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Fig. 1: Global view of the modified immunopeptidome.

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This is a summary of: Kacen, A. et al. Post-translational modifications reshape the antigenic landscape of the MHC I immunopeptidome in tumors. Nat. Biotechnol. https://doi.org/10.1038/s41587-022-01464-2 (2022)

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Capturing the diversity of protein modifications on presented tumor antigens.
Nat Biotechnol (2022). https://doi.org/10.1038/s41587-022-01465-1

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  • DOI: https://doi.org/10.1038/s41587-022-01465-1

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