Health & Medical

Multiple Myeloma Treatment: What’s New?

Multiple Myeloma Treatment: What’s New? thumbnail

Medically Reviewed by Melinda Ratini, DO, MS on June 27, 2022

Treatments for multiple myeloma have grown a great deal in the past few years. Newer drugs help people with this blood cancer live longer and enjoy a better quality of life.

Several drugs have been approved to treat multiple myeloma since 2015. Some can help when the disease comes back after treatment (called a relapse) or when the cancer doesn’t respond to the first line of treatment (called refractory multiple myeloma).

Some of these newer drugs are:

Belantamab mafodotin-blmf (Blenrep) is the first in a class of drugs called antibody drug conjugates (ADC). These meds combine a monoclonal antibody drug and chemotherapy in one drug. Belantamab mafodotin-blmf can treat people who’ve been already treated with at least four prior therapies, including:

  • An anti-CD38 monoclonal antibody like daratumumab (Darzalex). This targets a protein on the surface of myeloma cells called CD38.
  • A proteasome inhibitor like bortezomib (Velcade). This drug blocks substances called proteasomes, which help cancer cells recycle proteins they need to grow.
  • An immunomodulatory agent. These meds use your body’s defenses (your immune system) to attack myeloma cells. Examples of these drugs are lenalidomide (Revlimid), pomalidomide (Pomalyst), and thalidomide (Thalomid).

Belantamab mafodotin-blmf targets the protein BCMA (B-cell maturation antigen), which is the protein that protects the cancer cell. 

Ciltacabtagene autoleucel (Carvykti) is a type of CAR-T therapy. That means it uses cells from your immune system to fight cancer. Ciltacabtagene autoleucel can treat adults with relapsed or refractory multiple myeloma who’ve had four or more different types of treatment, including:

  • A proteasome inhibitor
  • An immunomodulatory agent
  • And an anti-CD38 monoclonal antibody 
READ:  No Time to Die Sets Multiple Records With a $119 Million International Box Office Debut

Each dose of the treatment is tailored for you using your own T cells — a type of disease-fighting white blood cell – to help attack the myeloma. Your treatment team collects and genetically changes your T cells, then puts them back into your body.

Daratumumab (Darzalex) is a monoclonal antibody. It revs up your immune system to help you fight the cancer.

You can take this drug either alone or combined with bortezomib (Velcade), melphalan (Alkeran), and prednisone – or with dexamethasone and lenalidomide (Revlimid). It depends on whether you’re newly diagnosed, prior treatments haven’t helped you, or the disease has relapsed.

Daratumumab targets a protein on the surface of myeloma cells called CD38. It seeks out the protein and then kills the cancer cells it’s attached to.

Elotuzumab(Empliciti) is another monoclonal antibody.  It searches for a molecule on cancer cells called SLAMF7.

It’s combined with other myeloma drugs: either with lenalidomide (Revlimid) and dexamethasone, or with dexamethasone and a newer drug called pomalidomide (Pomalyst). It works for people with more aggressive forms of myeloma.

Idecabtagene vicleucel (Abecma) was the first CAR-T therapy to treat adults with multiple myeloma. It’s for people who haven’t responded to — or whose disease has come back after — at least four different types of treatment.

Isatuximab (Sarclissais a monoclonal antibody that works similar to daratumumab. It’s used together with pomalidomide and dexamethasone for people who’ve tried at least two other treatments. It also targets CD38 and slows the growth of cancer. It can also be used with carfilzomib (Kyprolis) and dexamethasone, to treat people who have tried one to three other treatments.

READ:  Multiple reforms necessary to transform our education sector – Adutwum

Ixazomib (Ninlaro) is the first and only oral proteasome inhibitor taken by mouth that the FDA has approved for multiple myeloma. Proteasomes are enzyme complexes that help cancer cells recycle proteins they need to grow. Ixazomib blocks proteasomes to kill myeloma cells.

It’s combined with lenalidomide (Revlimid) and dexamethasone. It’s used in people who’ve tried at least one other myeloma treatment.

Selinexor(Xpoviois a newer type of multiple myeloma drug called a selective inhibitor of nuclear export (SINE). It works by blocking XPO1, a protein that allows cancer cells to thrive.

The FDA approved selinexor for treatment of relapsed or refractory disease. It’s combined with dexamethasone and is used to treat people who’ve tried at least four previous treatments. It can also be used with dexamethasone or bortezomib in people who have tried at least one other treatment.

What’s on the Horizon?

Some potential breakthroughs in multiple myeloma therapy are still in the test phase, but they seem very promising, says Hans C. Lee, MD, an assistant professor at the University of Texas MD Anderson Cancer Center in Houston.

For example, T-cell engagers are antibodies that fight cancer cells in two separate ways: They look for BCMA and T cells, which are part of your own immune system, Lee says.

One arm of the antibody searches for BCMA on the myeloma cell’s surface. The other arm looks for a protein called CD3 on T cells. Lee says it’s basically “the kiss of death” for the cancer cells. The T cell is activated (turned on), it comes into contact with the myeloma cell, then kills it, he says. These drugs are also called bispecific T-cell engager antibodies, or BiTEs.

READ:  Three Home-Based Visual Acuity Tests Validated

Another positive step for multiple myeloma treatment is the advance in genomic medicine, says Lee. Doctors are able to do a biopsy, or tissue sample, and see gene-related information about your cancer more quickly and cheaply than in the past. Lee says that hopefully, doctors will soon be able to use this data in real time, possibly to help find the ideal way to sequence your treatments or even to individualize treatment.

Read More

Learn More: healthy food near me,health care privacy part 2,health store near me,health triangle,health plan of san joaquin,health o meter scale,health hut,health partners plans,heath zenith,health related fitness,health o meter,health unlimited,health food near me,health gear inversion table,health warrior,no healthy upstream,health journeys,health right 360,healthx,health union,health unit coordinator salary,health gauge des moines,health village imaging,health gorilla,health zone,health nut cafe,health 3.0,how much health does the ender dragon have,health kick,health verity,health velocity capital,health quarters,how much health does the wither have,health 101,c health lebanon va,e health messaging,m health maple grove,healthxl,health 5e,i health inc

Leave a Reply

Your email address will not be published. Required fields are marked *