Eight people were taken to hospital following “severe turbulence” during a flight.
The airline said the plane “experienced sudden severe turbulence as it neared Florida”.
Seven passengers and a member of the cabin crew were treated in hospital after the plane landed safely, the company added.
The aircraft – an Airbus A320 – has now been taken out of service for inspection, JetBlue said.
The National Transportation Safety Board has opened an investigation into the incident.
Serious injuries as a result of turbulence remain rare.
A total of four passengers and 13 crew were seriously injured during passenger flights in the US in 2022, according to official data.
Last month, a Delta flight from Milan to Atlanta experienced major turbulence.
Footage of the flight showed oxygen masks that had fallen out from overhead compartments and one passenger holding a bag of ice to her head due to injuries.