Science & Nature

Researchers Discover a Key COVID “Weak Spot”

Researchers Discover a Key COVID “Weak Spot” thumbnail

Global COVID Variants

The discovery could potentially pave the way for new COVID treatments.

The University of British Columbia researchers have discovered a key vulnerability of major coronavirus variants.

The University of British Columbia researchers uncovered a key vulnerability in all main variants of the

SARS CoV 2 Spike and Ab6 Antibody Fragment

Cryo-electron microscopy reveals how the VH Ab6 antibody fragment (red) attaches to the vulnerable site on the SARS-CoV-2 spike protein (grey) to block the virus from binding with the human ACE2 cell receptor (blue). Credit: Dr. Sriram Subramaniam, UBC

Neutralizing antibodies can target the vulnerability, potentially opening the door for treatments that would be universally effective across variants.

The research, which was published in the journal DOI: 10.1038/s41467-022-32262-8

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