The study included two different samples of veterans with trauma exposure and high rates of PTSD and associated psychiatric conditions. They included a group of 434 relatively younger veterans (average age early 30s) who had served in the post-9/11 conflicts and a group of 647 trauma-exposed middle-age veterans and their trauma-exposed spouses (average age early 50s). Both groups were assessed for a range of psychological conditions and underwent a blood draw to obtain genetic information and to test for levels of a variety of inflammatory and neuropathological molecules. The younger cohort also underwent cognitive testing and a brain MRI.
The researchers then used the DNA methylation data obtained in each blood sample to measure “GrimAge” using an existing algorithm that is predictive of time to death. They then correlated GrimAge with a range of psychiatric diagnoses, biological markers, cognitive tests and metrics of brain morphology.
In addition to associations between PTSD and externalizing psychiatric disorders with the DNA methylation marker of shortened time-to-death, the study found that the GrimAge DNA methylation index was associated with a number of adverse clinical outcomes, including alterations in inflammation, oxidative stress, immune, and metabolic molecules, and with metrics of neuropathology such as cortical thinning, a blood-based measure of astrocyte damage, and cognitive decline.
“Collectively our findings suggest that a number of psychiatric disorders may increase risk for early death and underscore the importance of identification of those at greatest risk,” said Wolf.
According to her, the biomarkers associated with GrimAge could hold the key to identification of new biological treatments to slow or reverse the march towards premature death among those with symptoms of traumatic stress. “The ability to detect low levels of these molecules years before they may become clinically significant and hopefully be able to intervene early on in disease trajectories is critical for efforts to ultimately slow or reverse the adverse health consequences of traumatic stress.”
These finding appear online in the journal Translational Psychiatry.
Sage E. Hawn et al, For whom the bell tolls: psychopathological and neurobiological correlates of a DNA methylation index of time-to-death, Translational Psychiatry (2022). DOI: 10.1038/s41398-022-02164-w
Study of veterans finds PTSD and conditions such as substance misuse associated with a cellular marker for early death (2022, September 26)
retrieved 26 September 2022
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.
Learn More: healthy food near me,health care privacy part 2,health store near me,health triangle,health plan of san joaquin,health o meter scale,health hut,health partners plans,heath zenith,health related fitness,health o meter,health unlimited,health food near me,health gear inversion table,health warrior,no healthy upstream,health journeys,health right 360,healthx,health union,health unit coordinator salary,health gauge des moines,health village imaging,health gorilla,health zone,health nut cafe,health 3.0,how much health does the ender dragon have,health kick,health verity,health velocity capital,health quarters,how much health does the wither have,health 101,c health lebanon va,e health messaging,m health maple grove,healthxl,health 5e,i health inc