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The lysosomal degraders

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Inspired by PROTACs, new degraders are emerging that harness endocytosis and autophagy to send a wide array of targets to the lysosome for destruction.

Novel targeted degrader concepts are appearing almost daily. In September, Genentech researchers unveiled a cancer-targeting strategy that uses bispecific antibodies to induce degradation of cell membrane proteins — the latest addition to the fast-growing family of targeted degraders. The very next day, University of California, San Francisco biochemist James Wells published on bispecific antibodies that link cytokine receptors to extracellular and membrane protein targets. (EpiBiologics has licensed the technology.) These and other degraders take different roads, but the destination is the same: the lysosome.

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Fig. 1: There are multiple pathways to protein degradation.

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  1. Ann Arbor, MI, USA

    Ken Garber

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Garber, K. The lysosomal degraders.
Nat Biotechnol (2022).

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